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Dr. Steve Sjuggerud’s note: Last week, I asked one of the best investors I know to contribute one of his best investment ideas for readers of DailyWealth. Below is what San Francisco-based money manager Jeff Clark had to say:

Big Pharma… From Bad to Less Bad
by Jeff Clark,
editor The Big Trend Report
March 23, 2006

It's time to buy Big Pharma.

I can almost hear the collective groans. And, in the words of a former United States President, "I feel your pain."

It is more than just a little ironic that in an industry where the primary products are supposed to ease pain and suffering, shareholders have endured such tremendous agony.

Indeed, large-cap pharmaceutical stocks make up one of the worst performing market sectors over the past three years. Of course, that's to be expected when big names like Merck and Pfizer drop 40% and 33%, respectively. And, when even a stalwart stock like Johnson & Johnson can only put up a paltry 10% gain since this cyclical bull market began, then you know it's been a difficult three years.

But that's all about to change...

The recent performance of large cap pharmaceutical stocks is hinting at a new bullish Big Trend to get underway. And the last time this sector was poised as it is now it generated triple digit gains in just two years.

Suddenly, I don't hear the groaning anymore…

My friend Steve Sjuggerud often points out that the largest profits occur as the conditions surrounding a stock or industry move from bad to less bad. Not only do I agree with this concept, but history also proves it correct.

That's why it's so important to pay attention to the news flow surrounding a stock or an industry, and even more importantly, the market's reaction to that news flow. One of the surest ways to recognize that a stock is ready to change trend, from bearish to bullish or vice versa, is to note how that stock reacts to news.

For example, when a stock no longer reacts favorably to good news, that lack of action serves as a warning sign that the stock is preparing to trend lower. Conversely, and more importantly for our purposes, a stock that no longer declines on bad news is preparing to trend higher.

For most of the past three years, the news flow in the pharmaceutical sector has been decisively negative…

"Doctor Says Vioxx Can Cause Heart Attacks"

"Lipitor Linked to Liver, Kidney Damage"

"U.S. Probes Viagra Blindness Risk"

Indeed, as concerns about the industry's top three revenue generating products knocked out three legs of Big Pharma's stool, lawyers were working on how to take out the fourth…

On August 19, 2005, Big Pharma was hit with the verdict that threatened to topple the industry. An Angleton, Texas jury found that Merck was negligent in its marketing of Vioxx and awarded the plaintiff over $250 million in damages.

This was the first major case against Merck and it's marketing of Vioxx, and there were thousands more waiting to be heard. Certainly, any reasonable investor would expect to see Merck shares crash on the news and to witness a broad based sell-off in the pharmaceutical stocks in general. And, that's what we saw, sort of...

Merck shares dropped almost 8% on the news and the pharmaceutical sector, as represented by the Pharmaceutical HOLDRs Trust (PPH), fell 1.5%.

While no one likes to see their shares decline in value, Big Pharma shareholders had to be, at least, modestly relieved that the damage was not more severe. Of course, there were many more verdicts to come and the potential for a continuous stream of bad news ought to cause most reasonable investors to avoid the sector.

In December 2005, though, a funny thing happened...

U.S. Judge Eldon Fallon declared a mistrial in a Vioxx case after a Houston jury failed to reach a unanimous decision. Merck was widely expected to win this case, so having it declared a mistrial was certainly bad news for Merck shareholders.

Following the news, shares of Merck were basically unchanged. And, shares of the Pharmaceutical HOLDRs Trust (PPH) were actually up a fraction. The fact that pharmaceutical stocks didn't decline on the news of the mistrial was the first hint that the worst may be over for this sector.

Since Big Pharma investors have taken such a beating over the past three years, it may seem overly optimistic, or even a bit pathetic, to get excited about the stocks' failure to drop on bad news. But, when you're looking for the emergence of a new Big Trend, it often pays to reach for even the thinnest of branches.

Remember, the biggest gains often occur as an industry moves from bad to less bad.

Over the past few months, we've seen a few positive headlines that have helped to firm up the foundation of the industry -- Merck announced a major restructuring; Pfizer won a major ruling upholding its Lipitor patent.

We've witnessed positive technical action in the stocks, which indicates the sector is shifting its trend from bearish to bullish. And, we've seen an acceleration of money flow into Big Pharma stocks.

Consequently, it looks like things are getting less bad in Big Pharma…

A few months ago, I recommended my Big Trend Report subscribers purchase shares of Pharmaceutical HOLDRs Trust (PPH). I still think this basket of major pharmaceutical companies is a great buy…

PPH is an exchange-traded fund comprised of 21 different stocks in the pharmaceutical/biotechnology industry. The trust is heavily weighted in favor of large capitalization pharmaceutical stocks with Johnson & Johnson (JNJ), Pfizer (PFE), and Merck (MRK) making up more than 50% of the total weighting of the fund.

The large weighting in favor of JNJ, PFE, and MRK may be of concern to some investors, but I think it's an advantage. Indeed, the bulk of the pain in Big Pharma over the past three years was inflicted upon these three stocks. Consequently, if this sector rebounds, then I think these issues will make up the most ground.

The Big Trend in Big Pharma is just beginning… are you going to catch it?

Good Investing,

Jeff Clark, editor
The Big Trend Report

Editor's note: Jeff Clark is a regular contributor to DailyWealth, a free investment newsletter focused on the world's best contrarian opportunities. We write with a simple belief in mind: You don't have to take big risks to make big money with your investments.

Sign up today to read more investment ideas from Jeff Clark.

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GUNS AND BUTTER AND MORE GUNS

As the world’s developing economies like India, Brazil, and China get richer and more developed, DailyWealth will hazard a guess and say they will still have the desire to blow each other up.

With America leading the way with a proposed $440 billion defense budget in 2007, defense contractors like Northrop Grumman (NOC), Lockheed Martin (LMT), and General Dynamics (GD) are enjoying a bull market in the $1 trillion global arms industry… driving the benchmark Spade Defense Index to new highs.

We wish it were not so, but the producers of guns, missiles, tanks, bullets, and fighter jets are doing a brisk business.

The benchmark Spade Defense Index (2-year chart):

-Brian Hunt


“According to a new survey by the Pew Research Center, Republicans are happier than Democrats. Well of course they are, they own everything.”

-Jay Leno

“Nearly 70% of Americans own their homes, a record high, but the rate of homeownership for working families with children is lower than in 1978, according to a study being released Wednesday by the Center for Housing Policy.

The surprising trend is being driven by a combination of factors: soaring housing costs that have overshot wage increases, higher health care bills and a rise in the number of single parents.”

-USA Today

“Argentina revoked Suez SA's 30-year contract to supply water and sewage treatment to residents in and around Buenos Aires, putting management of the services back under government control.”

-Bloomberg

“Health insurance premiums rose 9.2% in 2005, more than 2.5 times the inflation rate. The average cost of U.S. family coverage was $10,880.”

-Investor’s Business Daily

A “BASE BUILDING” IN JAPAN

After a 36% increase in the final quarter of 2005, the Japanese stock market (as measured by the Nikkei) has spent the last three months in a sideways-moving base.

The “breather” in Japanese stocks has slowed the price appreciation of the iShares MSCI Japan Index Fund (EWJ). This diversified play on Japan has now cooled its investor hype and is virtually even for 2006.

Some of this fund’s largest weightings include dominant companies like Toyota (TM), Canon (CAJ), Sony (SNE), and Honda (HMC).

The Market Message From Minneapolis
March 22, 2006

Is Ben Bernanke Lying? Another Reason To Think Outside Your Borders
March 21, 2006

The Market Message From Minneapolis
March 20, 2006

Thinking Outside Your Borders… 7%+ On Your Cash
March 17, 2006

A Fourth Episode in Complacency
March 16, 2006

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